The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization

Human genetic studies have demonstrated that polymorphisms in different complement proteins can increase the risk for developing AMD. There are three pathways of complement activation, classical (CP), alternative (AP), and lectin (LP), which all activate a final common pathway. Proteins encoded by t...

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Main Authors: Rohrer, Bärbel, Coughlin, Beth, Kunchithapautham, Kannan, Long, Qin, Tomlinson, Stephen, Takahashi, Kazue, Holers, V. Michael
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063365/
https://ncbi.nlm.nih.gov/pubmed/21257205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2010.12.016
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