Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and γδT-cells

Neovascular age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV). An overactive complement system is associated with AMD pathogenesis, and serum pro-inflammatory cytokines, including IL-17, are elevated in AMD patients. IL-17 is produced by complement C5a-rec...

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Vydáno v:Sci Rep
Hlavní autoři: Coughlin, Beth, Schnabolk, Gloriane, Joseph, Kusumam, Raikwar, Himanshu, Kunchithapautham, Kannan, Johnson, Krista, Moore, Kristi, Wang, Yi, Rohrer, Bärbel
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814842/
https://ncbi.nlm.nih.gov/pubmed/27029558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23794
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