New Insights on Complement Inhibitor CD59 in Mouse Laser-Induced Choroidal Neovascularization: Mislocalization After Injury and Targeted Delivery for Protein Replacement

Purpose: The membrane attack complex (MAC) in choriocapillaris (CC) and retinal pigment epithelium (RPE) increase with age and disease (age-related macular degeneration). MAC assembly can be inhibited by CD59, a membrane-bound regulator. Here we further investigated the role of CD59 in murine choroi...

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Bibliographic Details
Published in:J Ocul Pharmacol Ther
Main Authors: Schnabolk, Gloriane, Beon, Mee Keong, Tomlinson, Stephen, Rohrer, Bärbel
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2017
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467148/
https://ncbi.nlm.nih.gov/pubmed/28333572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jop.2016.0101
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