Delivery of CR2-fH Using AAV Vector Therapy as Treatment Strategy in the Mouse Model of Choroidal Neovascularization

Complement activation plays a significant role in age-related macular degeneration (AMD) pathogenesis, and polymorphisms interfering with factor H (fH) function, a complement alternative pathway (AP) inhibitor, are associated with increased AMD risk. We have previously validated an AP inhibitor, a f...

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Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: Schnabolk, Gloriane, Parsons, Nathaniel, Obert, Elisabeth, Annamalai, Balasubramaniam, Nasarre, Cecile, Tomlinson, Stephen, Lewin, Alfred S., Rohrer, Bärbel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5723362/
https://ncbi.nlm.nih.gov/pubmed/29234687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.11.003
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