Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies

BACKGROUND: Glutamate excitotoxicity is thought to be involved in the pathogenesis of neurodegenerative disease. One potential source of glutamate is N-acetyl-aspartyl-glutamate (NAAG) which is hydrolyzed to glutamate and N-acetyl-aspartate (NAA) in a reaction catalyzed by glutamate carboxypeptidase...

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Detalhes bibliográficos
Main Authors: Rojas, Camilo, Stathis, Marigo, Polydefkis, Michael, Rudek, Michelle A, Zhao, Ming, Ebenezer, Gigi J, Slusher, Barbara S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063219/
https://ncbi.nlm.nih.gov/pubmed/21388540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-27
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