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Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method

The proton-coupled transporter (PCFT) mediates intestinal folate absorption and folate transport from blood across the choroid plexus. The membrane topology of PCFT has been defined using the substituted cysteine accessibility method; an intramolecular disulfide bond between the Cys 66 and 298 resid...

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Autori principali: Zhao, Rongbao, Shin, Daniel Sanghoon, Goldman, I. David
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062655/
https://ncbi.nlm.nih.gov/pubmed/21256110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2011.01.008
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