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Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking

The proton-coupled folate transporter (PCFT, SLC46A1) is required for intestinal folate absorption and folate homeostasis in humans. A homology model of PCFT, based upon the Escherichia coli glycerol 3-phosphate transporter structure, predicted that PCFT transmembrane domains (TMDs) 1, 2, 7, and 11...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Zhao, Rongbao, Najmi, Mitra, Fiser, Andras, Goldman, I. David
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825018/
https://ncbi.nlm.nih.gov/pubmed/26884338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.693929
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