Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouse

BACKGROUND: Several lines of evidence indicate that memory loss represents a synaptic failure caused by soluble amyloid β (Aβ) oligomers. However, the pathological relevance of Aβ oligomers (AβOs) as the trigger of synaptic or neuronal degeneration, and the possible mechanism underlying the neurotox...

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Main Authors: Takamura, Ayumi, Okamoto , Yasuhide, Kawarabayashi, Takeshi, Yokoseki, Tatsuki, Shibata, Masao, Mouri, Akihiko, Nabeshima, Toshitaka, Sun, Hui, Abe, Koji, Urisu, Tsuneo, Yamamoto, Naoki, Shoji, Mikio, Yanagisawa, Katsuhiko, Michikawa, Makoto, Matsubara, Etsuro
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061944/
https://ncbi.nlm.nih.gov/pubmed/21375782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-20
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