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Directed adenovirus evolution using engineered mutator viral polymerases

Adenoviruses (Ads) are the most frequently used viruses for oncolytic and gene therapy purposes. Most Ad-based vectors have been generated through rational design. Although this led to significant vector improvements, it is often hampered by an insufficient understanding of Ad’s intricate functions...

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Détails bibliographiques
Auteurs principaux: Uil, Taco G., Vellinga, Jort, de Vrij, Jeroen, van den Hengel, Sanne K., Rabelink, Martijn J. W. E., Cramer, Steve J., Eekels, Julia J. M., Ariyurek, Yavuz, van Galen, Michiel, Hoeben, Rob C.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2011
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061072/
https://ncbi.nlm.nih.gov/pubmed/21138963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1258
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