Truncating the i-leader open reading frame enhances release of human adenovirus type 5 in glioma cells

BACKGROUND: The survival of glioma patients with the current treatments is poor. Early clinical trails with replicating adenoviruses demonstrated the feasibility and safety of the use of adenoviruses as oncolytic agents. Antitumor efficacy has been moderate due to inefficient virus replication and s...

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Autori principali: van den Hengel, Sanne K, de Vrij, Jeroen, Uil, Taco G, Lamfers, Martine L, Sillevis Smitt, Peter AE, Hoeben, Rob C
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090740/
https://ncbi.nlm.nih.gov/pubmed/21477385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-8-162
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