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Efficient incorporation of a functional hyper-stable single-chain antibody fragment protein-IX fusion in the adenovirus capsid

Recombinant adenoviruses are frequently used as gene transfer vehicles for therapeutic gene delivery. Strategies to amend their tropism include the incorporation of polypeptides with high affinity for cellular receptors. Single-chain antibodies have a great potential to achieve such cell type-specif...

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Detalhes bibliográficos
Main Authors: Vellinga, Jort, De Vrij, Jeroen, Myhre, Susanna, Uil, Taco, Martineau, Pierre, Lindholm, Leif, Hoeben, Rob C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233715/
https://ncbi.nlm.nih.gov/pubmed/17268536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.gt.3302908
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