Spacers Increase the Accessibility of Peptide Ligands Linked to the Carboxyl Terminus of Adenovirus Minor Capsid Protein IX

The efficiency and specificity of gene transfer with human adenovirus (hAd)-derived gene transfer vectors would be improved if the native viral tropism could be modified. Here, we demonstrate that the minor capsid protein IX (pIX), which is present in 240 copies in the Ad capsid, can be exploited as...

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Hlavní autoři: Vellinga, Jort, Rabelink, Martijn J. W. E., Cramer, Steve J., van den Wollenberg, Diana J. M., Van der Meulen, Hans, Leppard, Keith N., Fallaux, Frits J., Hoeben, Rob C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Gene Therapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC371045/
https://ncbi.nlm.nih.gov/pubmed/15016870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.7.3470-3479.2004
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