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Blocking the Gate to Ligand Entry in Human Hemoglobin
His(E7) to Trp replacements in HbA lead to markedly biphasic bimolecular CO rebinding after laser photolysis. For isolated mutant subunits, the fraction of fast phase increases with increasing [CO], suggesting a competition between binding to an open conformation with an empty E7 channel and relaxat...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3060505/ https://ncbi.nlm.nih.gov/pubmed/21193395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.176271 |
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