Determination of Ligand Pathways in Globins: APOLAR TUNNELS VERSUS POLAR GATES

Although molecular dynamics simulations suggest multiple interior pathways for O(2) entry into and exit from globins, most experiments indicate well defined single pathways. In 2001, we highlighted the effects of large-to-small amino acid replacements on rates for ligand entry and exit onto the thre...

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Detalhes bibliográficos
Main Authors: Salter, Mallory D., Blouin, George C., Soman, Jayashree, Singleton, Eileen W., Dewilde, Sylvia, Moens, Luc, Pesce, Alessandra, Nardini, Marco, Bolognesi, Martino, Olson, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460423/
https://ncbi.nlm.nih.gov/pubmed/22859299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.392258
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