Determination of Ligand Pathways in Globins: APOLAR TUNNELS VERSUS POLAR GATES

Although molecular dynamics simulations suggest multiple interior pathways for O(2) entry into and exit from globins, most experiments indicate well defined single pathways. In 2001, we highlighted the effects of large-to-small amino acid replacements on rates for ligand entry and exit onto the thre...

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Autores principales: Salter, Mallory D., Blouin, George C., Soman, Jayashree, Singleton, Eileen W., Dewilde, Sylvia, Moens, Luc, Pesce, Alessandra, Nardini, Marco, Bolognesi, Martino, Olson, John S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Molecular Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460423/
https://ncbi.nlm.nih.gov/pubmed/22859299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.392258
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