Determination of Ligand Pathways in Globins: APOLAR TUNNELS VERSUS POLAR GATES

Although molecular dynamics simulations suggest multiple interior pathways for O(2) entry into and exit from globins, most experiments indicate well defined single pathways. In 2001, we highlighted the effects of large-to-small amino acid replacements on rates for ligand entry and exit onto the thre...

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Bibliografiske detaljer
Main Authors:	Salter, Mallory D., Blouin, George C., Soman, Jayashree, Singleton, Eileen W., Dewilde, Sylvia, Moens, Luc, Pesce, Alessandra, Nardini, Marco, Bolognesi, Martino, Olson, John S.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Biochemistry and Molecular Biology 2012
Fag:	Molecular Biophysics
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3460423/ https://ncbi.nlm.nih.gov/pubmed/22859299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.392258
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Determination of Ligand Pathways in Globins: APOLAR TUNNELS VERSUS POLAR GATES

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