Ligand Migration in the Apolar Tunnel of Cerebratulus lacteus Mini-Hemoglobin

The large apolar tunnel traversing the mini-hemoglobin from Cerebratulus lacteus (CerHb) has been examined by x-ray crystallography, ligand binding kinetics, and molecular dynamic simulations. The addition of 10 atm of xenon causes loss of diffraction in wild-type (wt) CerHbO(2) crystals, but Leu-86...

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Detalhes bibliográficos
Main Authors: Pesce, Alessandra, Nardini, Marco, Dewilde, Sylvia, Capece, Luciana, Martí, Marcelo A., Congia, Sonia, Salter, Mallory D., Blouin, George C., Estrin, Darío A., Ascenzi, Paolo, Moens, Luc, Bolognesi, Martino, Olson, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037647/
https://ncbi.nlm.nih.gov/pubmed/21147768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.169045
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