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Distal Histidine Stabilizes Bound O(2) and Acts as a Gate for Ligand Entry in Both Subunits of Adult Human Hemoglobin
The role of the distal histidine in regulating ligand binding to adult human hemoglobin (HbA) was re-examined systematically by preparing His(E7) to Gly, Ala, Leu, Gln, Phe, and Trp mutants of both Hb subunits. Rate constants for O(2), CO, and NO binding were measured using rapid mixing and laser ph...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2838306/ https://ncbi.nlm.nih.gov/pubmed/20080971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.053934 |
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