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Role of Heme Pocket Water in Allosteric Regulation of Ligand Reactivity in Human Hemoglobin

Water molecules can enter the heme pocket after the escape of ligand from myoglobins and hemoglobins, hydrogen bond with the distal histidine, and introduce steric barriers to ligand rebinding. The photodissociated CO complexes of human hemoglobin and its isolated α and β chains were subjected to sp...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Biochemistry
Egile Nagusiak: Esquerra, Raymond M., Bibi, Bushra M., Tipgunlakant, Pooncharas, Birukou, Ivan, Soman, Jayashree, Olson, John S., Kliger, David S., Goldbeck, Robert A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978812/
https://ncbi.nlm.nih.gov/pubmed/27355904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00081
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