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Role of Heme Pocket Water in Allosteric Regulation of Ligand Reactivity in Human Hemoglobin
Water molecules can enter the heme pocket after the escape of ligand from myoglobins and hemoglobins, hydrogen bond with the distal histidine, and introduce steric barriers to ligand rebinding. The photodissociated CO complexes of human hemoglobin and its isolated α and β chains were subjected to sp...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4978812/ https://ncbi.nlm.nih.gov/pubmed/27355904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00081 |
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