The Th17-Defining Transcription Factor RORγt Promotes Glomerulonephritis

Although Th17 responses may contribute to the pathogenesis of glomerulonephritis, whether the key transcription factor in Th17 cell development, RORγt, also promotes glomerulonephritis is unknown. Here, we induced crescentic glomerulonephritis in wild-type and RORγt-deficient (RORγt(−/−)) mice. RORγ...

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Detaylı Bibliyografya
Asıl Yazarlar: Steinmetz, Oliver M., Summers, Shaun A., Gan, Poh-Yi, Semple, Timothy, Holdsworth, Stephen R., Kitching, A. Richard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Nephrology 2011
Konular:
Basic Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060441/
https://ncbi.nlm.nih.gov/pubmed/21183590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010040435
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