The Th17-Defining Transcription Factor RORγt Promotes Glomerulonephritis

Although Th17 responses may contribute to the pathogenesis of glomerulonephritis, whether the key transcription factor in Th17 cell development, RORγt, also promotes glomerulonephritis is unknown. Here, we induced crescentic glomerulonephritis in wild-type and RORγt-deficient (RORγt(−/−)) mice. RORγ...

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Bibliografiske detaljer
Main Authors: Steinmetz, Oliver M., Summers, Shaun A., Gan, Poh-Yi, Semple, Timothy, Holdsworth, Stephen R., Kitching, A. Richard
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2011
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060441/
https://ncbi.nlm.nih.gov/pubmed/21183590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010040435
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