Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth

Carcinoma associated fibroblasts (CAFs) that express α-smooth-muscle-actin (αSMA) contribute to cancer progression, but their precise origin and role is unclear. Using mouse models of inflammation-induced gastric cancer, we show that at least 20% of CAFs originate from bone marrow (BM) and derive fr...

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Detalhes bibliográficos
Main Authors: Quante, Michael, Tu, Shui Ping, Tomita, Hiroyuki, Gonda, Tamas, Wang, Sophie S.W., Takashi, Shigeo, Baik, Gwang Ho, Shibata, Wataru, DiPrete, Bethany, Betz, Kelly S., Friedman, Richard, Varro, Andrea, Tycko, Benjamin, Wang, Timothy C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060401/
https://ncbi.nlm.nih.gov/pubmed/21316604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.01.020
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