GLOBAL HYPOMETHYLATION OF GENOMIC DNA IN CANCER-ASSOCIATED MYOFIBROBLASTS

Global loss of methylation has long been recognized as a feature of the malignant epithelial component in human carcinomas. Here we show evidence for this same type of epigenetic alteration in cancer-associated stromal myofibroblasts. We used methylation-sensitive SNP array analysis (MSNP) to profil...

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Autors principals: Jiang, Le, Gonda, Tamas A., Gamble, Mary V., Salas, Martha, Seshan, Venkatraman, Tu, Shuiping, Twaddell, William S., Hegyi, Peter, Lazar, Gyorgy, Steele, Islay, Varro, Andrea, Wang, Timothy C., Tycko, Benjamin
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670548/
https://ncbi.nlm.nih.gov/pubmed/19047171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1319
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