Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice

Hyperproliferation of the colonic epithelium, leading to expansion of colonic crypt progenitors, is a recognized risk factor for colorectal cancer. Overexpression of progastrin, a nonamidated and incompletely processed product of the gastrin gene, has been shown to induce colonic hyperproliferation...

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Detalhes bibliográficos
Main Authors: Jin, Guangchun, Ramanathan, Vigneshwaran, Quante, Michael, Baik, Gwang Ho, Yang, Xiangdong, Wang, Sophie S.W., Tu, Shuiping, Gordon, Shanisha A.K., Pritchard, David Mark, Varro, Andrea, Shulkes, Arthur, Wang, Timothy C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735927/
https://ncbi.nlm.nih.gov/pubmed/19652364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38918
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