Requirement for kinase-induced conformational change in eukaryotic initiation factor 2α (eIF2α) restricts phosphorylation of Ser51

As phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) on Ser51 inhibits protein synthesis, cells restrict this phosphorylation to the antiviral protein kinase PKR and related eIF2α kinases. In the crystal structure of the PKR–eIF2α complex, the C-terminal lobe of the kinase conta...

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Detalhes bibliográficos
Main Authors: Dey, Madhusudan, Velyvis, Algirdas, Li, John J., Chiu, Elaine, Chiovitti, David, Kay, Lewis E., Sicheri, Frank, Dever, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060252/
https://ncbi.nlm.nih.gov/pubmed/21368187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014872108
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