Allosteric Modulation of the Calcium-sensing Receptor by γ-Glutamyl Peptides: INHIBITION OF PTH SECRETION, SUPPRESSION OF INTRACELLULAR cAMP LEVELS, AND A COMMON MECHANISM OF ACTION WITH l-AMINO ACIDS

γ-Glutamyl peptides were identified previously as novel positive allosteric modulators of Ca(2+)(o)-dependent intracellular Ca(2+) mobilization in HEK-293 cells that bind in the calcium-sensing receptor VFT domain. In the current study, we investigated whether γ-glutamyl-tripeptides including γ-Glu-...

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Detalhes bibliográficos
Main Authors: Broadhead, Geoffrey K., Mun, Hee-chang, Avlani, Vimesh A., Jourdon, Orane, Church, W. Bret, Christopoulos, Arthur, Delbridge, Leigh, Conigrave, Arthur D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059007/
https://ncbi.nlm.nih.gov/pubmed/21187282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149724
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