Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1

Mutation at the R132 residue of IDH1, frequently found in gliomas and acute myelogenous leukemia, creates a neo-enzyme that produces 2-hydroxyglutarate (2-HG) from α-ketoglutarate (α-KG). We sought to therapeutically exploit this neo-reaction in mutant IDH1 cells which requires α-KG derived from glu...

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Autors principals: Seltzer, Meghan J., Bennett, Bryson D., Joshi, Avadhut D., Gao, Ping, Thomas, Ajit G., Ferraris, Dana V., Tsukamoto, Takashi, Rojas, Camilo J., Slusher, Barbara S., Rabinowitz, Joshua D., Dang, Chi V., Riggins, Gregory J.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058858/
https://ncbi.nlm.nih.gov/pubmed/21045145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1666
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