Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression

Acid sphingomyelinase (ASM) regulates the homeostasis of sphingolipids, including ceramides and sphingosine-1-phosphate (S1P). Because sphingolipids regulate AKT activation, we investigated the role of ASM in hepatic glucose and lipid metabolism. Initially, we overexpressed ASM in the livers of wild...

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Hauptverfasser: Osawa, Yosuke, Seki, Ekihiro, Kodama, Yuzo, Suetsugu, Atsushi, Miura, Kouichi, Adachi, Masayuki, Ito, Hiroyasu, Shiratori, Yoshimune, Banno, Yoshiko, Olefsky, Jerrold M., Nagaki, Masahito, Moriwaki, Hisataka, Brenner, David A., Seishima, Mitsuru
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2011
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058702/
https://ncbi.nlm.nih.gov/pubmed/21163859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-168351
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