Liver acid sphingomyelinase inhibits growth of metastatic colon cancer

Acid sphingomyelinase (ASM) regulates the homeostasis of sphingolipids, including ceramides and sphingosine-1-phosphate (S1P). These sphingolipids regulate carcinogenesis and proliferation, survival, and apoptosis of cancer cells. However, the role of ASM in host defense against liver metastasis rem...

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Hlavní autoři: Osawa, Yosuke, Suetsugu, Atsushi, Matsushima-Nishiwaki, Rie, Yasuda, Ichiro, Saibara, Toshiji, Moriwaki, Hisataka, Seishima, Mitsuru, Kozawa, Osamu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561803/
https://ncbi.nlm.nih.gov/pubmed/23298833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65188
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