A novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells

Histone deacetylase (HDAC) inhibitors exhibit a unique ability to degrade topoisomerase (topo)IIα in hepatocellular carcinoma (HCC) cells, which contrasts with the effect of topoII-targeted drugs on topoIIβ degradation. This selective degradation might foster novel strategies for HCC treatment in li...

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Main Authors: Chen, Mei-Chuan, Chen, Chun-Han, Chuang, Hsiao-Ching, Kulp, Samuel K., Teng, Che-Ming, Chen, Ching-Shih
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058595/
https://ncbi.nlm.nih.gov/pubmed/21254166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23964
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