A Novel Mechanism by Which Thiazolidinediones Facilitate the Proteasomal Degradation of Cyclin D1 in Cancer Cells

This study identifies a novel mechanism by which thiazolidinediones mediate cyclin D1 repression in prostate cancer cells. Based on the finding that the thiazolidinedione family of peroxisome proliferator-activated receptor γ (PPARγ) agonists mediated PPARγ-independent cyclin D1 degradation, we deve...

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Main Authors: Wei, Shuo, Yang, Hsiao-Ching, Chuang, Hsiao-Ching, Yang, Jian, Kulp, Samuel K., Lu, Pei-Jung, Lai, Ming-Derg, Chen, Ching-Shih
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546561/
https://ncbi.nlm.nih.gov/pubmed/18650423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802160200
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