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β(2)-microglobulin forms 3D domain-swapped amyloid fibrils with disulfide linkages

β(2)-microglobulin (β(2)m) is the light chain of type I major histocompatibility complex. It deposits as amyloid fibrils within joints during long-term hemodialysis treatment. Despite the devastating effects of dialysis-related amyloidosis, full understanding of how fibrils form from soluble β(2)m r...

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Détails bibliographiques
Auteurs principaux: Liu, Cong, Sawaya, Michael R., Eisenberg, David
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058263/
https://ncbi.nlm.nih.gov/pubmed/21131979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1948
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