Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

Macrophages mediate crucial innate immune responses via caspase-1-dependent processing and secretion of IL-1β and IL-18. While wild type Salmonella typhimurium infection is lethal to mice, a strain that persistently expresses flagellin was cleared by the cytosolic flagellin detection pathway via NLR...

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Main Authors: Miao, Edward A., Leaf, Irina A., Treuting, Piper M., Mao, Dat P., Dors, Monica, Sarkar, Anasuya, Warren, Sarah E., Wewers, Mark D., Aderem, Alan
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058225/
https://ncbi.nlm.nih.gov/pubmed/21057511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1960
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