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Gasdermins: Effectors of pyroptosis
Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase-11/4/5, which cleave gasdermin D, separating its N-terminal pore-forming domain (PFD) from the C-terminal repressor dom...
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| Publicado no: | Trends Cell Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5565696/ https://ncbi.nlm.nih.gov/pubmed/28619472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2017.05.005 |
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