Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

The mammalian innate immune system uses Toll-like receptors (TLRs) and Nod-LRRs (NLRs) to detect microbial components during infection. Often these molecules work in concert; for example, the TLRs can stimulate the production of the proforms of the cytokines IL-1β and IL-18, whereas certain NLRs tri...

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Autori principali: Miao, Edward A., Mao, Dat P., Yudkovsky, Natalya, Bonneau, Richard, Lorang, Cynthia G., Warren, Sarah E., Leaf, Irina A., Aderem, Alan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840275/
https://ncbi.nlm.nih.gov/pubmed/20133635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913087107
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