Canonical inflammasomes drive IFN-γ to prime caspase-11 in defense against a cytosol-invasive bacterium

The inflammatory caspases-1 and -11 are activated in response to different agonists and act independently to induce pyroptosis. In the context of IL-1β/IL-18 secretion however, in vitro studies indicate that caspase-11 acts upstream of NLRP3 and caspase-1. By contrast, studying infection in vivo by...

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Bibliografske podrobnosti
izdano v:Cell Host Microbe
Main Authors: Aachoui, Youssef, Kajiwara, Yuji, Leaf, Irina A, Mao, Dat, Ting, Jenny P-Y, Coers, Jörn, Aderem, Alan, Buxbaum, Joseph D, Miao, Edward A
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567510/
https://ncbi.nlm.nih.gov/pubmed/26320999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.07.016
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