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Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
Macrophages mediate crucial innate immune responses via caspase-1-dependent processing and secretion of IL-1β and IL-18. While wild type Salmonella typhimurium infection is lethal to mice, a strain that persistently expresses flagellin was cleared by the cytosolic flagellin detection pathway via NLR...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3058225/ https://ncbi.nlm.nih.gov/pubmed/21057511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1960 |
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