Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell specific manner

The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), which naturally persists in rodents, represents a model for HIV, HBV and HCV. Cleavage of the viral glycoprotein precursor by membrane-bound transcription factor peptidase, site 1 (Mbtps1 or Site-1 Protease) is crucial for the life...

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Huvudupphovsmän: Popkin, Daniel L., Teijaro, John R., Sullivan, Brian M., Urata, Shuzo, Rutschmann, Sophie, de la Torre, Juan Carlos, Kunz, Stefan, Beutler, Bruce, Oldstone, Michael
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058147/
https://ncbi.nlm.nih.gov/pubmed/21402360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.02.006
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