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Persistent LCMV infection is controlled by blockade of type 1 interferon signaling

During persistent viral infections, chronic immune activation, negative immune regulator expression, an elevated interferon signature and lymphoid tissue destruction correlate with disease progression. Here, we demonstrate that blockade of type 1 interferon (IFN-I) signaling using a type 1 interfero...

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Main Authors: Teijaro, John R., Ng, Cherie, Lee, Andrew M., Sullivan, Brian M., Sheehan, Kathleen C.F., Welch, Megan, Schreiber, Robert D., de la Torre, Juan Carlos, Oldstone, Michael B. A.
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640797/
https://ncbi.nlm.nih.gov/pubmed/23580529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1235214
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