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Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection
Type I interferons (IFN-I) are critical for antiviral immunity; however, chronic IFN-I signaling is associated with hyperimmune activation and disease progression in persistent infections. We demonstrated in mice that blockade of IFN-I signaling diminished chronic immune activation and immune suppre...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3704950/ https://ncbi.nlm.nih.gov/pubmed/23580528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1235208 |
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