Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell specific manner

The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), which naturally persists in rodents, represents a model for HIV, HBV and HCV. Cleavage of the viral glycoprotein precursor by membrane-bound transcription factor peptidase, site 1 (Mbtps1 or Site-1 Protease) is crucial for the life...

Full description

Saved in:
Bibliographic Details
Main Authors: Popkin, Daniel L., Teijaro, John R., Sullivan, Brian M., Urata, Shuzo, Rutschmann, Sophie, de la Torre, Juan Carlos, Kunz, Stefan, Beutler, Bruce, Oldstone, Michael
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058147/
https://ncbi.nlm.nih.gov/pubmed/21402360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.02.006
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items