Induction of cyclin E–cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events

The c-myc gene has been implicated in three distinct genetic programs regulating cell proliferation: control of cyclin E–cdk2 kinase activity, E2F-dependent transcription and cell growth. We have now used p27(–/–) fibroblasts to dissect these downstream signalling pathways. In these cells, activatio...

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Hlavní autoři: Beier, Rudolf, Bürgin, Andrea, Kiermaier, Astrid, Fero, Matthew, Karsunky, Holger, Saffrich, Rainer, Möröy, Tarik, Ansorge, Wilhelm, Roberts, Jim, Eilers, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2000
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC305784/
https://ncbi.nlm.nih.gov/pubmed/11060032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.21.5813
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