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Induction of cyclin E–cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events
The c-myc gene has been implicated in three distinct genetic programs regulating cell proliferation: control of cyclin E–cdk2 kinase activity, E2F-dependent transcription and cell growth. We have now used p27(–/–) fibroblasts to dissect these downstream signalling pathways. In these cells, activatio...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305784/ https://ncbi.nlm.nih.gov/pubmed/11060032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.21.5813 |
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