Rho Kinase II Phosphorylation of the Lipoprotein Receptor LR11/SORLA Alters Amyloid-β Production

LR11, also known as SorLA, is a mosaic low-density lipoprotein receptor that exerts multiple influences on Alzheimer disease susceptibility. LR11 interacts with the amyloid-β precursor protein (APP) and regulates APP traffic and processing to amyloid-β peptide (Aβ). The functional domains of LR11 su...

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Hlavní autoři: Herskowitz, Jeremy H., Seyfried, Nicholas T., Gearing, Marla, Kahn, Richard A., Peng, Junmin, Levey, Allan I., Lah, James J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057792/
https://ncbi.nlm.nih.gov/pubmed/21147781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167239
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