Hematopoiesis and leukemogenesis in mice expressing oncogenic Nras(G12D) from the endogenous locus

NRAS is frequently mutated in hematologic malignancies. We generated Mx1-Cre, Lox-STOP-Lox (LSL)-Nras(G12D) mice to comprehensively analyze the phenotypic, cellular, and biochemical consequences of endogenous oncogenic Nras expression in hematopoietic cells. Here we show that Mx1-Cre, LSL-Nras(G12D)...

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Detalhes bibliográficos
Main Authors: Li, Qing, Haigis, Kevin M., McDaniel, Andrew, Harding-Theobald, Emily, Kogan, Scott C., Akagi, Keiko, Wong, Jasmine C. Y., Braun, Benjamin S., Wolff, Linda, Jacks, Tyler, Shannon, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056645/
https://ncbi.nlm.nih.gov/pubmed/21163920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-280750
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