CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP

The retrovirus, human T-cell–lymphotrophic virus-1 (HTLV-I) is the etiologic agent of adult T-cell leukemia (ATL) and the neurological disorder HTLV-I–associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-I–encoded protein tax constitutively activates interleukin-2 (IL-2), IL-9, and...

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Bibliographische Detailangaben
Hauptverfasser: Ju, Wei, Zhang, Meili, Jiang, Jian-kang, Thomas, Craig J., Oh, Unsong, Bryant, Bonita R., Chen, Jing, Sato, Noriko, Tagaya, Yutaka, Morris, John C., Janik, John E., Jacobson, Steven, Waldmann, Thomas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2011
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056641/
https://ncbi.nlm.nih.gov/pubmed/21106989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-305425
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