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A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection
CONTEXT: Although ZAP-70 is required for T-cell development, it’s unclear how this kinase controls both positive and negative selection. OBJECTIVE AND METHODS: Using OT-I pre-selection thymocytes and a panel of pMHC ligands of defined affinity, the recruitment, phosphorylation and activity of ZAP-70...
Shranjeno v:
| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056388/ https://ncbi.nlm.nih.gov/pubmed/20945976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10799893.2010.518151 |
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