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A phosphotyrosine displacement mechanism for activation of Src by PTPα
Protein tyrosine phosphatase α (PTPα) is believed to dephosphorylate physiologically the Src proto-oncogene at phosphotyrosine (pTyr)527, a critical negative-regulatory residue. It thereby activates Src, and PTPα overexpression neoplastically transforms NIH 3T3 cells. pTyr789 in PTPα is constitutive...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2000
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305636/ https://ncbi.nlm.nih.gov/pubmed/10698938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.5.964 |
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