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A phosphotyrosine displacement mechanism for activation of Src by PTPα

Protein tyrosine phosphatase α (PTPα) is believed to dephosphorylate physiologically the Src proto-oncogene at phosphotyrosine (pTyr)527, a critical negative-regulatory residue. It thereby activates Src, and PTPα overexpression neoplastically transforms NIH 3T3 cells. pTyr789 in PTPα is constitutive...

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Detalhes bibliográficos
Main Authors: Zheng, Xin-Min, Resnick, Ross J., Shalloway, David
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC305636/
https://ncbi.nlm.nih.gov/pubmed/10698938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.5.964
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