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Mitotic Activation of Protein-tyrosine Phosphatase α and Regulation of Its Src-mediated Transforming Activity by Its Sites of Protein Kinase C Phosphorylation

During mitosis, the catalytic activity of protein-tyrosine phosphatase (PTP) α is enhanced, and its inhibitory binding to Grb2, which specifically blocks Src dephosphorylation, is decreased. These effects act synergistically to activate Src in mitosis. We show here that these effects are abrogated b...

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Publicat a:J Biol Chem
Autors principals: Zheng, Xin-Min, Resnick, Ross J., Shalloway, David
Format: Artigo
Idioma:Inglês
Publicat: 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641391/
https://ncbi.nlm.nih.gov/pubmed/11923305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M201394200
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