Activation of Src and transformation by an RPTPα splice mutant found in human tumours

Receptor protein tyrosine phosphatase α (RPTPα)-mediated Src activation is required for survival of tested human colon and oestrogen receptor-negative breast cancer cell lines. To explore whether mutated RPTPα participates in human carcinogenesis, we sequenced RPTPα cDNAs from five types of human tu...

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Main Authors: Huang, Jian, Yao, Ling, Xu, Rongting, Wu, Huacheng, Wang, Min, White, Brian S, Shalloway, David, Zheng, Xinmin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160186/
https://ncbi.nlm.nih.gov/pubmed/21725282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.212
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