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Two mechanisms activate PTPα during mitosis
We show that, dependent on serine hyperphosphorylation, protein tyrosine phosphatase α (PTPα) is activated by two different mechanisms during mitosis: its specific activity increases and its inhibitory binding to Grb2 decreases. The latter effect probably abates Grb2 inhibition of the phosphotyrosin...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125689/ https://ncbi.nlm.nih.gov/pubmed/11689444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.21.6037 |
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